This tutorial begins with a broad overview of challenges in emerging mixed signal systems. After describing the system-level requirements along with the architecture and circuit needs, specific circuit and system solutions will be discussed to highlight promising approaches. Design techniques for advanced analog- and mixed signal circuit blocks such as phase-locked loops and analog-to-digital converters will be covered in detail. Finally, the modeling and analysis of substrate noise coupling in mixed-signal integrated circuits is addressed. This day long tutorial addresses both the system- and circuit-level aspects of emerging mixed-signal systems. Analysis and design techniques to implement analog to digital converters, phase-locked loops, and the impact of substrate noise on these circuits in large system-on-chips will be discussed. The tutorial is categorized into the following four categories.