How the Dorsal gradient works: insights from postgenome technologies.

TitleHow the Dorsal gradient works: insights from postgenome technologies.
Publication TypeJournal Article
Year of Publication2008
AuthorsHong, J. - W., D. Hendrix, D. Papatsenko, and M. S. Levine
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue51
Pagination20072-6
Date Published12/2008
ISSN1091-6490
Keywordsanimals, Body Patterning, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, Embryonic Induction, Gene Expression Regulation, Developmental, Nuclear Proteins, Phosphoproteins, Transcription Factors
Abstract

Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximately 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.

DOI10.1073/pnas.0806476105
Alternate JournalProc. Natl. Acad. Sci. U.S.A.