Monday, October 28, 2019 - 4:00pm to 4:50pm
Gilfillan Auditorium

Speaker Information

Larisa Tereshchenko
Associate professor of medicine
Knight Cardiovascular Institute

Abstract

Heart disease is the #1 killer in the United States. Sudden cardiac death is a major contributor to cardiovascular mortality and a tragic event for a community and family members. Understanding mechanisms of cardiac arrhythmias is a key factor for further reduction of cardiovascular disease burden and mortality. For initiation of arrhythmia, two components are necessary: trigger and the susceptible electrophysiological substrate. Advances in computer science, digital signal processing, and understanding of cardiac arrhythmia mechanisms led to the development of novel mechanistic electrocardiographic and vectorcardiographic measures. We use a widely available, inexpensive, and non-invasive tool (resting 12-lead ECG) to characterize the electrophysiological substrate of cardiac arrhythmias and sudden cardiac death. Then, we study associations of electrocardiographic phenotype with genomics to understand underlying biology of the electrophysiological substrate. In my talk I will present my translational program, my effort of building Big Data resource (ECGome consortium) and outline opportunities for our collaboration/opportunities for students.

Speaker Bio

Dr. Tereshchenko is an associate professor of medicine in the Knight Cardiovascular Institute. She received MD degree with Honors from the Tyumen Medical School (USSR) in 1986. She was the first-prize winner of the Internal Medicine Competition of the Russian Federation in 1985-86. Dr. Tereshchenko completed Cardiology & Cardiac Electrophysiology Fellowship and received a Ph.D. degree from Novosibirsk Medical School in 1994. Dr. Tereshchenko was an Assistant Professor of Medicine in the Tyumen Medical School in 1994-2004.

In 2004, Dr. Tereshchenko joined the faculty of the Washington University School of Medicine, where she initiated and conducted a prospective cohort study of ICD patients (ICD-EGMs study). After completion of cardiac electrophysiology fellowship at the Johns Hopkins Hospital, she joined the faculty of the Johns Hopkins School of Medicine, Cardiovascular Division. She established translational electrophysiology laboratory and developed several novel methods of electrocardiogram analyses, such as dynamic vectorcardiography, global electrical heterogeneity, and measurement of inapparent ventricular conduction. In 2013 Dr. Tereshchenko was awarded NIH R01 award “Novel ECG measures and risk of sudden cardiac death” and moved to the Oregon Health & Science University in Portland, Oregon. She maintains NIH funding of her laboratory.

Dr. Tereshchenko is a Fellow of Heart Rhythm Society, American Heart Association, and American College of Cardiology. She was the President of the International Congress of Electrocardiology hosted in Portland in 2017, and a member of a Board of Directors (Treasurer) of the International Society for Computerized Electrocardiology in 2014-2017. She was awarded the DelMar Junior Investigator Award, awarded by the International Society for Holter and Noninvasive Electrocardiology. Dr. Tereshchenko is an inventor on two patents, an author of more than 100 manuscripts, 3 book chapters, and a member of an Editorial Board of the leading electrophysiology journals (Circulation: Arrhythmia and Electrophysiology, Heart Rhythm, among others).