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miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data

TitlemiRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data
Publication TypeJournal Article
Year of Publication2010
AuthorsHendrix, D., M. Levine, and W. Shi
JournalGenome Biology
Volume11
Issue4
PaginationR39
Date Published04/2010
ISSN1465-6906
Abstract

MicroRNAs (miRs) have been broadly implicated in animal development and disease. We developed a novel computational strategy for the systematic, whole-genome identification of miRs from high throughput sequencing information. This method, miRTRAP, incorporates the mechanisms of miR biogenesis and includes additional criteria regarding the prevalence and quality of small RNAs arising from the antisense strand and neighboring loci. This program was applied to the simple chordate Ciona intestinalis and identified nearly 400 putative miR loci.

DOI10.1186/gb-2010-11-4-r39
Short TitleGenome BiolGenome Biology