Software/hardware systems are increasingly, seamlessly, and tightly integrated into physical entities ranging from machines, devices, vehicles, buildings, to human bodies. Recent advances in sensing, actuating, computing, control, and networking, have enabled a smart networked world where every physical object is empowered by intelligence and interconnected providing unprecedented efficiency, safety, security, productivity, and previously unavailable functionalities to virtually all areas of our society ranging from transportation, energy, healthcare, infrastructure, to emergency response. However, these “complex networks” of a massive number of heterogeneous nodes pose numerous challenges. Limited resources, high mobility, and sparse/random distributions of nodes cause complex network topologies such as network segmentation, network holes, and asymmetric links. Disparate nodes with manifold roles exhibit various and dynamic network traffic patterns. The explosion of data demands even resource-constrained devices such as smartphones to store and process big data. In this talk, by formulating the network connectivity restoration as a multi-objective optimization problem, I will present both centralized and distributed approaches to revitalize the segmented network. I will then introduce the design and implementation of a location-based unified routing framework that seamlessly consolidates our protocols designed for essential routing primitives to effectively manage dynamic traffic patterns. Finally, the design of a mobile cloud system that enables mobile devices with big-data processing and high-performance computing capabilities, will be presented. This talk will be concluded with my future research plans on Cyber Physical Systems/Internet of Things.